Increased prevalence of liver fibrosis in people living with HIV without viral hepatitis compared to population controls
The Journal of Infectious Diseases Dec 21, 2020
Kirkegaard-Klitbo DM, Bendtsen F, Lundgren J, et al. - Compared to population controls, researchers assessed the prevalence and factors correlated with liver fibrosis in people living with HIV (PWH) via this cross-sectional cohort study comparing 342 PWH with 2,190 population controls aged 50-70 years. They conducted transient elastography and elevated liver stiffness measurement (LSM) characterized as 7.6kPa as a proxy for significant liver fibrosis. Logistic regression was applied to estimate adjusted odds ratios and 95% confidence intervals (95% CI). Compared with population controls, the prevalence of elevated LSM was higher in PWH (7% vs 12%). The results exhibited that higher age, BMI, ALT, previous exposure to didanosine, and a positive HIV status were independently correlated with higher odds of elevated LSM.
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