Groznik M, et al. - Given the vital significance of the early diagnosis of acute posttraumatic osteomyelitis (POM) for avoiding devastating complications in patients with high-energy tibial fractures, researchers sought the utility of the biochemical and immunoinflammatory patient profile in predicting the development of acute POM in these patients. They analyzed 86 patients after high-energy injury to the shin requiring primary surgical treatment (open or closed reduction and internal fixation of tibial fracture) in this prospective nonrandomised cohort study and discovered that the development of POM is associated with increased C-reactive protein (CRP) on admission (ADD), first postoperative day (POD1) and decreased albumins on fourth-postoperative day (POD4). Findings suggest that prediction of posttraumatic osteomyelitis could be improved using the perioperative inflammatory biomarker CRP in combination with postoperative albumins levels and other associated independent risk factors such as the extent of soft tissue damage, multiple fractures, transfusion rate, need for conversion primary external fixation to intramedullary (IM) nailing or locking plate fixation.