Kugathasan P, et al. - In comparison to the general population, researchers explored the connection of single- and multimorbidity with mortality rates in patients with schizophrenia. Between 1995 and 2015, the study sample consisted of participants resident in Denmark. Study participants included 30,210 patients with schizophrenia (mean age(SD) = 32.6(11.4), males = 57.2%), and 5,402,611 from the general population (mean age(SD) = 33.0(14.5), males = 50.4%). According to findings, schizophrenia patients showed higher mortality at all multimorbidity levels and a doubled mortality rate across all somatic diseases (ie, infections, cancer, endocrine, neurologic, cardiovascular, respiratory, digestive, skin, musculoskeletal, and urogenital diseases) vs the general population. Schizophrenia patients exhibited a hazard ratio > 2, compared with the general population across all somatic diseases, and respiratory, digestive and cardiovascular diseases displayed the greatest contributions to death. The findings suggest that the main driver of excess mortality is the clusters and trajectories of symptoms associated with schizophrenia.