Huang Y, Xu Y, Liu A., et al. - This study draws on data from The Irish LongituDinal Study on Ageing (TILDA) to assess the correlation of serum levels of glycosylated hemoglobin (GHb) with the risk of depressive symptoms in a middle-aged and elderly population (aged ≥ 49 years) with cancer that was further stratified by those with taking antidepressant medications. The sample consisted of 204 participants with cancer. After changes have been made to different lifestyle variables in an adult population with cancer, serum GHb levels are positively and significantly correlated with depressive symptoms. These results were independent of age, gender, body mass index (BMI), currently married, education, smoking status, drink alcohol, systolic and diastolic blood pressure (BP), physical activity, self-reported cardiovascular diseases and laboratory measurement in participants with cancer. Higher serum GHb levels in those with cancer correlated to higher prevalence of depression events during a follow-up of 4 years, as seen in the sensitivity analysis.