Fialho GL, et al. - Authors wanted to assess cardiac stiffness by echocardiography and its association with clinical, structural, and autonomic variables in people with epilepsy (PWE) vs healthy controls. For this study, a 12-lead electrocardiogram, treadmill testing, and transthoracic echocardiography from 30 patients with temporal lobe epilepsy (TLE) without any known cardiovascular disorders were compared to 30 individuals without epilepsy matched by sex, age, and body mass index. In multiple regressions, autonomic dysfunction explained 52% of stiffness. Additionally, carbamazepine treatment and polytherapy with antiepileptic drugs (AEDs) each explained 6%. An increase was noted in stiffness in young patients with TLE. TLE was also connected to autonomic dysfunction and, to a lesser extent, carbamazepine use and polytherapy with AEDs.