Sohn AH, Chalermchockcharoenkit A, Teeraananchai S, et al. - Risk for anogenital human papillomavirus (HPV) infection is reported to be higher for youth with perinatally acquired HIV (YPHIV). In Thailand and Vietnam, a cohort of YPHIV and HIV-negative youth was enrolled, matched by age and lifetime sex partners; the cohort was followed for 144 weeks (to 2017). Annual pelvic examinations were performed among participants with samples taken for HPV genotyping. Simultaneous HPV detection in multiple anogenital compartments (cervical, vaginal, anal) described concordant infection; when the same type was identified in successive compartments (cervicovaginal to/from anal), it is termed sequential infection. Enrollment of a total of 93 YPHIV and 99 HIV-negative women was performed; their median age was 19 years (interquartile range, 18–20 years). The one factor identified to be independently linked with both concordant and sequential high-risk HPV infection was perinatally acquired HIV. Based on finding, they recommend prioritizing children and adolescents with perinatally acquired HIV for HPV vaccination, and emphasize inclusion of cervical cancer screening as part of routine HIV care for sexually active YPHIV.