Watson KT, Simard JF, Henderson VW, et al. - Researchers identified positive predictive value of three surrogate measures of insulin resistance (high triglyceride-HDL [high-density lipoprotein] ratio; prediabetes, as indicated by fasting plasma glucose level; and high central adiposity, as measured by waist circumference) for incident major depressive disorder in a 9-year follow-up period among adults with no history of depression or anxiety disorder.

• A multisite longitudinal study, the Netherlands Study of Depression and Anxiety (NESDA), was conducted to assess the course and consequences of depressive and anxiety disorders in adults.

• There were a total of 601 NESDA participants (18–65 years old) without a lifetime history of depression or anxiety disorders.

• Major depressive disorder developed during follow-up in 14% of the sample.

• Higher triglyceride-HDL ratio, as well as higher fasting plasma glucose levels and higher waist circumference, was positively linked with an increased risk for incident major depression.

• A positive correlation was observed between the development of prediabetes in the 2-year period after study enrollment and incident major depressive disorder.