Matsuo K, et al. - In this retrospective study, researchers used data from the Surveillance, Epidemiology, and End Result Program between 1973 and 2013 to assess incidences and risk factors for metachronous vulvar, vaginal, and anal malignancies following a cervical cancer diagnosis. They evaluated cumulative incidences of vulvar, vaginal, and anal cancers after the diagnosis of cervical cancer and used multivariable analysis to determine independent risk factors for these metachronous cancers. They reported a rare incidence of ano-genital cancers, but the rate of these cancers showed a continuous increase over time following a cervical cancer diagnosis. Risk factors for metachronous vulvar cancer included older age, squamous histology, and radiotherapy use. Older age and black race were risk factors for metachronous vaginal cancer, while only older age was a risk factor for metachronous anal cancer. Overall, for the detection of these metachronous malignancies, particularly in those with risk factors, it is justified to conduct long-term follow-up and surveillance after cervical cancer treatment.