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Incidence trends and risk factors of lung cancer in never smokers: Pooled analyses of seven cohorts

International Journal of Cancer Aug 20, 2021

Rissanen E, Heikkinen S, Seppä K, et al. - Lung cancer incidence trend is declining among never-smoker men but not in never-smoker women, likely due to tobacco control measures targeting working places and thus resulting in decreased passive smoking in men more than in women.

  • Data were pooled from seven Finnish health cohorts with 106,193 never smokers.

  • Never smoking men were 31,859 and never smoking women were 74,334.

  • Total 47 and 155 lung cancers were detected in these respective groups.

  • The average annual percent change of lung cancer incidence was −3.30% and 0.00% in never smoking men and in never smoking women, respectively.

  • Of five examined risk factors (education, alcohol intake, physical activity, height, and BMI), only greater height in females had a statistically significant elevated risk of lung cancer (multivariate HR = 1.84).

  • Possibly, exposure to passive smoking among women has continued longer in the absence of tobacco control measures targeted to domestic environments.

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