Pellegrini M, Bernabei F, Barbato F, et al. - In this investigation involving 283 patients who underwent hematopoietic stem cell transplantation (HSCT) between 2005 and 2020, researchers sought to assess the incidence, risk factors and complications of ocular graft-vs-host disease (GVHD) in a large single center study. Data reported that the cumulative incidence of ocular GVHD was 19.7% at 1 year, 29.3% at 2 years, 40.7% at 3 years, 47.2% at 4 years and 49.7% at 5 years. According to this retrospective observational case series, in the five years after HSCT, half of the patients developed ocular GVHD. Significant predictors of ocular GVHD were older age, female sex, use of PBSC and acute GVHD disease. Hematologists and ophthalmologists must be conscious of its vision threatening complications.