Rezoagli E, Bonaventura A, Coutinho JM, et al. - The incidence of cerebral vein thrombosis (CVT) was found to be comparable to that reported in population-based studies after the year 2000 in a major epidemiological investigation. The rate of CVT in women has risen over time. In patients with concomitant ICH, in-hospital CFR was low but not negligible. In-hospital mortality was predicted by age, ICH, and a high number of comorbidities. Although its high prevalence was not confirmed by internal validation, pyogenic CVT was not a predictor of in-hospital CFR.

• In total, 1,718 patients were hospitalized for CVT, with 134 patients experiencing a concomitant ICH.

• The overall CVT incidence rate was 11.6 per 1,000,000 inhabitants, with a sex-specific rate of 15.1 and 7.8 per 1,000,000 in females and males, respectively.

• CVT incidence increased significantly in women during the study period, with the highest incidence occurring between the ages of 40 and 44.

• The in-hospital CFR was 3%, with no difference between pyogenic and nonpyogenic CVT. When compared with patients without ICH, patients with concomitant ICH had a higher in-hospital CFR. With increasing Charlson comorbidity index, in-hospital CFR increased progressively. In-hospital mortality was predicted by age, Charlson comorbidity index ≥ 4, and ICH.