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Incidence rate of advanced chronic kidney disease among privately insured adults with neurodevelopmental disabilities

Clinical Epidemiology Mar 04, 2020

Whitney DG, et al. - This study was undertaken to calculate the incidence rate of advanced chronic kidney disease (CKD) for adults with NDDs and compare the incidence rate to adults without neurodevelopmental disabilities (NDDs). They carried out data from the Optum Clinformatics Data Mart to perform this retrospective cohort study. The calendar year 2013 was applied to distinguish eligible participants: individuals ≥ 18 years of age and without advanced CKD. Individuals were accompanied from 01/01/2014 to advanced CKD, loss to follow-up, death, or end of the study period (12/31/2017), whichever came first. In the year 2013, the diagnostic, procedure and diagnosis-related group codes distinguished NDDs (intellectual disabilities, cerebral palsy, autism spectrum disorders), incident cases of advanced CKD (CKD stages 4+), diabetes, cardiovascular diseases, and hypertension. This study applied Cox regression to calculate the hazard ratio (HR and 95% CI) for advanced CKD, comparing adults with NDDs to adults without NDDs while adjusting for covariates. The results of this study imply that individuals with NDDs have a greater risk of advanced CKD than do adults without NDDs, and that difference is not defined by covariates used in our analysis.
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