Osler M, et al. - In this Danish cohort study, researchers analyzed the incidence of suicidal and violent behavior after the beginning of antidepressant medication. They estimated the purchase of antidepressant medication, suicide, suicide attempts, and conviction for violent crime among cohorts of 997,911 conscripts and 95,794 patients with a first-time affective disorder in Danish registries between 1997 through 2015. According to results, antidepressant treatment was taken by 16.5% of conscripts and 73.7% of patients with affective disorders. During the first 28 days after initiation, 3-4 times higher incidence of suicide was noted vs the incidence rates reported in the following year in both cohorts. During the 28 days before and after the initiation of antidepressants, the frequency of attempted suicide was highest, while rates of violent crime were comparable before and after initiation. Such occurrence patterns are independent of the antidepressant category. Findings suggested that higher suicidal behaviour rates in the weeks following the beginning of antidepressant medication are likely to reflect the severity of the disease and a delay in mood response.