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Incidence of residual neuromuscular blockade in children below 3 years after a single bolus of cisatracurium 0.1 mg/kg: A quality assurance study

Acta Anaesthesiologica Scandinavica Jan 30, 2020

Vested M, et al. - In this quality assurance study enrolling patients (n = 40; ≤ 3 years of age) scheduled for cleft lip and palate repair, researchers assessed the proportion of patients having residual block (train-of-four (TOF) ratio < 0.9) upon the end of operation following a bolus of cisatracurium 0.1 mg/kg. The good quality was considered if less than 10% of the study population had residual block upon the termination of surgery. The participants were administered general anaesthesia using either sevoflurane and fentanyl (n = 20) or propofol and remifentanil (n = 20). By means of acceleromyography, TOF stimulation was applied on the tibial nerve. To facilitate tracheal intubation, cisatracurium 0.1 mg/kg was given. Experts noted that following the delivery of a single bolus of cisatracurium 0.1 mg/kg, the presence of residual neuromuscular blockade (TOF ratio <0.9) was evident in 8% of the children but they could not exclude that the true proportion was around 20%.
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