Desbiens LC, et al. - By examining a prospective population-based survey, CARTaGENE, involving 40- to 69-year-old people from Quebec (Canada), researchers assessed the link between early chronic kidney disease (CKD) and fracture incidence at all sites across age and gender among middle-aged people. This inquiry included 19,391 people (756 CKD Stage 3; 9114 Stage 2; 9521 non-CKD). A median follow-up of 70 months was performed, during which, the occurrence of 829 fractures was reported. In unadjusted and adjusted models, increased fracture incidence was shown in relation to estimated glomerular filtration rates (eGFRs) of ≤ 60 mL/min/1.73 m² vs the median eGFR of 90 mL/min/1.73 m². Findings revealed that even early CKD raises the incidence of fracture, specifically among younger people and in men.