Wiener S, et al. - This study investigated incident prostate cancer, both clinically significant and insignificant, in patients who had an initial biopsy suggesting either atypical small acinar proliferation (ASAP), high grade prostatic intraepithelial neoplasia (HGPIN), or benign tissue. No difference was observed in the repeated biopsy-suggested rates of clinically significant prostate cancer between patients initially diagnosed with ASAP, HGPIN, or benign tissue. High rates of prostate cancer following ASAP diagnosis seemed to be largely ascribed to differences in the rate of clinically insignificant disease.