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Incidence of and factors associated with prolonged and persistent postoperative opioid use in children 0–18 years of age

Anesthesia & Analgesia Sep 19, 2020

Ward A, De Souza E, Miller D, et al. - Using a national administrative claims database, researchers examined the risk of prolonged and persistent postoperative opioid use (filling ≥ 60 days’ supply of opioids 90–365 days after surgery) after common surgeries among pediatric patients of all ages compared with children who do not undergo surgery. Further, they sought factors linked with these issues. The database yielded data from 175,878 surgical visits by opioid-naïve children aged ≤ 18 years who underwent ≥ 1 of the 20 most common surgeries from the 4 age groups (ages 0–<2, 2–<6, 6–<12, and 12–18) between December 31, 2002, and December 30, 2017, and who filled a perioperative opioid prescription 30 days before to 14 days after surgery. In the multivariable models for ages 0–<12 years, prolonged opioid use was observed in correlation with only few surgical procedures and none of the other variables of interest. In the models for ages 12–18 years, prolonged opioid use was observed in correlation with 10 surgical procedures and 5 other variables of interest. Less than 0.1% of patients in all age groups showed persistent postoperative opioid use.

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