Doshi R, et al. - From January 2010 through December 2014, data were obtained from the Healthcare Cost and Utilization Project’s Nationwide Inpatient Sample database to examine incidence, characteristics, mortality and predictors of mortality related to toxic megacolon (TM). It was observed that higher age, neurological disorder, coagulopathy, chronic pulmonary disease, heart failure, and renal failure were correlated with greater risk of in-hospital mortality in patients with TM. TM is seen more in women than men, affecting whites more than non-whites. IBD is the most common reason for hospital admission, followed by septicemia and intestinal infections. Overall in-hospital mortality was 7.9%. Researchers reported that TM was a serious condition with high in-hospital mortality, so management of TM requires an inter-disciplinary team approach with close monitoring.