Goudzwaard JA, de Ronde-Tillmans MJAG, de Jager TAJ, et al. - Among older patients receiving transcatheter aortic valve implantation (TAVI), researchers assessed the incidence, determinants as well as the results of postoperative delirium (POD), utilizing a prospective, observational registry, named TAVI Care and Cure program. This registry included patients referred for TAVI at Erasmus University Medical Centre. Overall participants were 543. The incidence of POD was estimated to be 14% (75/543 patients), and a drop in POD incidence, from 18% in 2014 to 7% in 2017, was reported. Older age, higher prevalence of renal dysfunction and previous stroke, and more frequent frailty were noted in patients who developed POD. The factors that were identified to be significantly related to POD, from a procedural perspective, were general anesthesia, non-transfemoral access and longer procedural time. In those who encountered POD and those who did not, the 1-year survival rate was estimated to be 68% and 85%, respectively. Overall, findings highlight a frequent occurrence of POD post-TAVI, as well as its link with increased mortality. It might be speculated that delirium frequency may be decreased via patient selection and the minimalistic approach of TAVI.