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Incidence, co-occurrence, and evolution of long-COVID features: A 6-month retrospective cohort study of 273,618 survivors of COVID-19

PLoS Medicine Oct 03, 2021

Taquet M, Dercon Q, Luciano S, et al. - Long-COVID clinical characteristics were commonly detected and co-occurred, with some specificity to COVID-19, albeit they were also seen following influenza. Depending on demographics and illness severity, several long-COVID clinical profiles were detected.

  • The authors carried out a retrospective cohort study based on linked electronic health records (EHRs) data from 81 million patients involving 273,618 COVID-19 survivors.

  • The study discovered that 1 in every 3 patients had one or more signs of long-COVID documented between 3 and 6 months after a COVID-19 diagnosis.

  • This was much greater than following the influenza pandemic.

  • Two out of every 5 patients who had long-COVID features in the 3- to 6-month period had no record of any such feature in the prior 3 months.

  • Long-COVID characteristics were more common in individuals with more severe COVID-19 illness, and slightly more common in females and young adults.

  • Both white and non-white patients were affected equally.

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