Osazuwa-Peters N, Barnes JM, Okafor SI, et al. - This population-based cross-sectional study was undertaken to determine if the risk of suicide among patients with head and neck cancer (HNC) varies by rural vs urban or metropolitan residence status. Data from 134,510 HNC patients (101,142 men [75.2%]; mean [SE] age, 57.7 [10.3] years) were analyzed, and 405 suicides were identified. Suicide mortality rates in metropolitan counties were 59.2 per 100,000 person-years, 64.0 per 100,000 person-years in urban counties, and 126.7 per 100,000 person-years in rural counties. According to the findings of this cross-sectional study, suicide risk is elevated in general among HNC patients, but it is significantly higher in rural patients. Because of the high risk of suicide among residents with HNC in rural areas, effective suicide prevention strategies in the population of patients with HNC must account for rural health.