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Incidence and risk of necrotizing enterocolitis in Denmark from 1994-2014

PLoS Neglected Tropical Diseases Jul 14, 2019

Juhl SM, et al. - In this retrospective, observational cohort study, all registered liveborn infants in Denmark from January 1, 1994 to December 31, 2014 were assessed to see if the higher incidence of necrotizing enterocolitis (NEC) seen in Denmark during the last 20 years could be explained by higher neonatal survival. Death was reported for 8,059 of 1,351,675 infants included in the cohort. Among all infants, risk of death significantly declined over the study period. They calculated an incidence of 7.4 per 10,000 live-born infants after NEC was diagnosed in 994 infants. Over the study period, an increase in the overall incidence of NEC was seen, but, considering the increased survival, there was no increase in the overall risk of NEC. Still, the most premature infants seemed to have an increased risk of NEC which was concealed by a decreased risk in term infants.

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