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Incidence and risk factors for severe preeclampsia, hemolysis, elevated liver enzymes, and low platelet count syndrome, and eclampsia at preterm and term gestation: A population-based study

American Journal of Obstetrics and Gynecology Jun 04, 2021

Lisonkova S, Bone JN, Muraca GM, et al. - Via performing a retrospective, population-based cohort study including all women with a singleton hospital birth in Canada (excluding Quebec) from 2012 to 2016 (N = 1,078,323), researchers herein investigated the gestational age–specific incidence rates and risk factors for severe preeclampsia, hemolysis, elevated liver enzymes, and low platelet count syndrome, and eclampsia. Severe preeclampsia (n = 2,533), hemolysis, elevated liver enzymes, and low platelet count syndrome (n = 2,663), and eclampsia (n = 465) were noted at following rates: 2.35, 2.47, and 0.43 per 1,000 singleton pregnancies, respectively. A decline in the risk for severe preeclampsia was noted at term, an increase in eclampsia risk was noted at term, and similar risk for hemolysis, elevated liver enzymes, and low platelet count syndrome was noted for preterm and term gestation. An increased risk for eclampsia and term-onset severe preeclampsia was recorded in correlation with young maternal age. A stronger association of prepregnancy comorbidity and fetal congenital anomalies was observed with severe preeclampsia, hemolysis, elevated liver enzymes, and low platelet count syndrome, and eclampsia at preterm gestation.

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