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Incidence and risk factors for severe preeclampsia, HELLP syndrome and eclampsia at preterm and term gestation: A population-based study

American Journal of Obstetrics and Gynecology May 13, 2021

Lisonkova S, Bone JN, Muraca GM, et al. - In this study, gestational age-specific incidence rates and risk factors for severe preeclampsia, HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome, and eclampsia were evaluated. Researchers conducted a retrospective population-based cohort study including all women with a singleton hospital birth in Canada (excluding Quebec), 2012/13-2015/16 (N=1,078,323). Independent risk factors (e.g., maternal age, chronic comorbidity) for each primary outcome were evaluated by using Cox regression, and differences in effects at preterm vs. term gestation (< 37 vs. ≥ 37 weeks) were assessed. The results of this study displayed that the risk of severe preeclampsia declined at term, eclampsia risk elevated at term and HELLP syndrome risk was similar at preterm and term gestation. It was shown that young maternal age was correlated with an elevated risk of eclampsia and term-onset severe preeclampsia. It was shown that pre-pregnancy comorbidity and fetal congenital anomalies were more strongly correlated with severe preeclampsia, HELLP syndrome, and eclampsia at preterm gestation.

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