Mahal BA, Catalano PJ, Haddad RI, et al. - Using the Surveillance, Epidemiology, and End Results HPV (human papillomavirus) Status Database, researchers focused on the incidence and demographic burden of HPV-positive oropharyngeal head and neck squamous cell carcinoma (OPSCC) in the United States (US). They analyzed 12,017 patients who were diagnosed, from 2013-2014, with head and neck squamous cell carcinoma (HNSCC) of pharyngeal subsites including OPSCC and non-OPSCC HNSCC subsites (hypopharynx, nasopharynx, and other pharynx). In the United States, the incidence of HPV-positive OPSCC was estimated to be 4.61 per 100,000 persons. White male patients younger than 65 experienced most of the HPV-positive OPSCC cases; it was the sixth most common incident non-skin cancer. The favorable prognosis related to HPV seemed to be restricted to the oropharynx.