Pazderska A, et al. - The tie-up between waist circumference (WC) and indices of glucose and lipid metabolism were evaluated by the authors in women with and without polycystic ovary syndrome (PCOS). Findings reported that some cardiometabolic abnormalities in PCOS were associated with central obesity. The following adjustment for WC did not appear to vary from normal individuals. It was discovered that the waist circumference measurement encompassed the potential to take precedence over PCOS status as part of the analysis of cardiometabolic risk in reproductive-age women.

Methods

• For this study, researchers performed
• An exploratory cross-sectional study, which examined the correlation of potential cardiometabolic risk markers (PCOS status, anthropometric measures, hsCRP, HOMA-IR, SHBG, testosterone) with indices of glucose (frequently sampled intravenous glucose tolerance test) and lipid metabolism (postprandial studies and lipoprotein particle size) in 61 women with (n = 29) and without (n = 32) PCOS
• A cross-sectional study in 103 PCOS women and 102 BMI-matched controls, that investigated if between-group differences in indices of lipid and glucose metabolism persist after adjusting for WC.
• For making the PCOS diagnosis, NIH criteria were used.

Results

• Study 1:
• Univariate correlations and stepwise regression modeling determined the waist circumference (WC).
• WC served as a better surrogate compared to the PCOS status.
• WC independently speculated multiple variables of glucose and lipid metabolism.
• Study 2:
• Findings illustrated that the fasting insulin and triglyceride, hsCRP and insulin resistance (according to HOMA-IR and SiM [Avignon index]) were greater.
• On the other hand, lower fasting HDL was found in women with PCOS than among BMI-matched women without PCOS.
• Data did not exhibit the persistence of these differences when a subset of 80 women with PCOS was compared with 80 women without PCOS, pair-matched for WC.