Da Silva T, Hafizi S, Watts JJ, et al. - In this cross-sectional analysis of long-term cannabis users (n = 24) and non–cannabis-using controls (n = 27), researchers focused on neuroimmune activation or 18-kDa translocator protein (TSPO) levels in long-term cannabis users. They also assessed behavioral measures and inflammatory blood biomarkers in correlation with brain TSPO levels. Findings revealed the presence of higher TSPO levels in cannabis users, especially in those with cannabis use disorder, compared with those in non–cannabis-using controls. They also identified the association of greater brain TSPO levels with chronic stress and anxiety as well as higher circulating C-reactive protein levels. In order to better appreciate the role of cannabinoids and TSPO in neuroimmune signaling, the requirement for more complementary preclinical systems was highlighted.