Soreide E, Denbeigh JM, Lewallen EA, et al. - Eighteen New Zealand rabbits underwent bilateral anterior cruciate ligament reconstruction by autograft, FiberTape, or FiberTape-augmented autograft in order to evaluate the potential of a biologically enhanced matrix material for ligament reconstruction to endure tensile forces within the joint and enhance ligament regeneration required to regain joint function. Improved biomechanical stability was exhibited by FiberTape alone or FiberTape-augmented autograft at eight weeks, in comparison with autograft relative to ultimate load to failure, elongation, and energy absorption. FiberTape-grafted samples also illustrated raised BMD in the bone tunnel. Histological assessment displayed integration of all grafts in the bone tunnels via formation of new bone, and controlled signs of inflammation, in all. In all samples, a lack of longer inflammation was validated by quantification of inflammation biomarkers. Nevertheless, along the suture tape materials, no regeneration of ligament-like tissue was noted. Except for one autograft failure, no adverse events were discovered. Thus, these results suggests that in a confirmed rabbit model, FiberTape raises the biomechanical performance of intra-articular ligament reconstructions at eight weeks. Moreover, within this period, FiberTape did not adversely impact bone tunnel healing or invoke a longer rise in inflammation.