LaVigne AW, et al. - In this retrospective study, investigators assessed 58 subjects with squamous cell cancer of the head and neck with unknown primary (head and neck CUP) who received intensity-modulated radiation therapy (IMRT) at the Dana Farber Cancer Institute between August 2004 and July 2013 to evaluate the influence of changes in mucosal dose on development of laryngeal strictures and percutaneous endoscopic gastrostomy (PEG) dependence. They observed a decline in PEG dependence for candidates treated with 56 Gy. No important differences were noted between any recurrences for groups treated to 56 vs ≥60 Gy to the mucosal surfaces. They also observed significant improvements in swallowing toxicity by 56 Gy IMRT-based mucosal dose.