Ghuman NK, Raikar S, Gothwal M, et al. - Researchers here examined if and how intentional endometrial injury/scratch in the early proliferative phase of stimulated cycle affects reproductive outcomes (clinical and ongoing pregnancy rates and miscarriage occurrence) of intra-uterine insemination treatment (IUI). In this prospective, randomized control interventional study, they randomly allocated 150 eligible couples requiring IUI treatment to either control or intervention group. In the trial participants, up to 3 cycles ovulation induction with clomiphene citrate and intra-uterine insemination was performed. In addition, endometrial scratch injury was induced in women in intervention group on day 6-7 of their stimulated cycle.  The groups were similar in terms of cumulative clinical pregnancy rates, biochemical pregnancy rates and ongoing pregnancy rates. Likewise, no statistically significant difference was noted in terms of the relative risk of miscarriage occurrence in the intervention arm vs control group. As the endometrial scratch injury in intra-uterine insemination treatment is moderately painful and have uncertain beneficial influence on reproductive outcomes, there was insufficient evidence to defend its use.