Lee HY - In view of the importance of the development of an alternative medicine to treat atopic dermatitis (AD) from natural sources, the researcher sought to improve skin barrier dysfunction by enhancing the differentiation of human keratinocytes with the fermented Scutellaria baicalensis. Results suggested that the skin barrier dysfunction was improved by the fermented extract, and for skin clinical trials to treat AD, ointment with 1%-5% (v/v) of the extract be directly used.