Guevara-Cruz M, Flores-López AG, Aguilar-López M, et al. - Researchers made a lifestyle intervention to reduce the dysbiosis of gut microbiota and decrease the biochemical abnormalities of Metabolic syndrome (MetS). In 1,065 individuals of Mexico City, Mexico, the prevalence of MetS was assessed. The prevalence of MetS was 53%, also, the higher the BMI, the higher the gut microbiota dysbiosis. The greater the Homeostatic Model Assessment for Insulin Resistance, the lower the high-density lipoprotein cholesterol concentration. Subsequent to 15 days on a low-saturated-fat diet, there was a 24% decrease in serum triglycerides and following a 75-day lifestyle intervention, MetS was diminished by 44.8%, with a decline in low-density lipoprotein cholesterol, small low-density lipoprotein particles, glucose intolerance, lipopolysaccharide, and branched-chain amino acid. The randomized control-placebo study explicated that following the lifestyle intervention, there was a reduction in the dysbiosis of the gut microbiota related to a decrease in the Prevotella/Bacteroides ratio and an increase in the abundance of Akkermansia muciniphila and Faecalibacterium prausnitzii. Therefore, a lifestyle intervention significantly reduced MetS components, small low-density lipoprotein particle concentration, gut microbiota dysbiosis, and metabolic endotoxemia, diminishing the risk of atherosclerosis.