Löffler MT, Jacob A, Valentinitsch A, et al. - Through 84 patients aged 50 years and older, who had routine CT including the lumbar spine and dual-energy x-ray absorptiometry (DXA) within a 12-month period (baseline) as well as follow-up imaging following at least 12 months or who maintained an incident vertebral fracture documented earlier, researchers contrasted opportunistic quantitative CT (QCT) with DXA in their ability to prognosticate incident vertebral fractures. Sixteen individuals had incident vertebral fractures exhibiting lower mean bone mineral density (BMD)_QCT vs individuals without fracture. The hazard ratio progressed per SD in BMD_QCT, as well as following adjusting for age, sex, and prevalent fractures for the risk of incident vertebral fractures. A statistically notable rise in relative hazard per SD reduction in T-score was only noted following age and sex adjustment for DXA. The predictability of incident vertebral fractures was great by BMD_QCT and non-marked by T-scores. Good long-term stability was demonstrated by asynchronously calibrated CT scanners. Therefore, the opportunistic screening of mainly neurosurgical and oncologic individuals in CT performed for implications other than densitometry permitted for better risk evaluation of imminent vertebral fractures in comparison with dedicated DXA.