Improved outcome of Pythium keratitis with a combined triple drug regimen of linezolid and azithromycin
Cornea Jun 14, 2021
Sane SS, Madduri B, Mohan N, et al. - Researchers conducted the study for describing the clinical characteristics, microbiological profile, and outcome of a series of cases of Pythium keratitis treated with topical and oral linezolid and topical azithromycin eye drops. This was a retrospective interventional case series of Pythium keratitis cases that were microbiologically and/or histopathologically proven between October 2016 and December 2019. All patients were given oral linezolid as well as topical linezolid and/or azithromycin eye drops. Over a long period of time, the dual topical drug regimen with oral linezolid has good cure rates (over 80%) for Pythium keratitis. It is advised to continue medical therapy even in large infiltrates because more than two-thirds resolved.
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