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Impaired peripheral insulin sensitivity in non-obese Japanese with type 2 diabetes mellitus and fatty liver

Journal of Diabetes Investigation Aug 28, 2017

Furukawa Y, et al. – In this study, researchers included 29 non–obese Japanese patients with early type 2 diabetes mellitus. Clinicians exhibited evidence that the metabolic features of non–obese Japanese type 2 diabetic patients with fatty liver (FL) include impaired peripheral insulin sensitivity, fat accumulation and related metabolic disorders, such as elevated FFA, low HMW–adiponectin and low grade inflammation.

Methods
  • Researchers included 29 non-obese (BMI<25 kg/m2) Japanese patients with early type 2 diabetes mellitus.
  • Based on intra-hepatic lipid (IHL) level measured by 1H-magnetic resonance spectroscopy, they categorized participants into the FL (IHL ≥5%, n=7) and non-FL groups (IHL<5%, n=22).

Results
  • Evidence suggested that peripheral insulin sensitivity measured by hyperinsulinemic euglycemic clamp was ~25% lower in the FL group than in non-FL group, while hepatic insulin sensitivity was comparable between the two groups.
  • The data demonstrated that the subcutaneous fat area was larger, free fatty acid level was higher, C-reactive protein was higher, and high molecular weight-adiponectin was lower in the FL group than the non-FL group.
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