Furukawa Y, et al. – In this study, researchers included 29 non–obese Japanese patients with early type 2 diabetes mellitus. Clinicians exhibited evidence that the metabolic features of non–obese Japanese type 2 diabetic patients with fatty liver (FL) include impaired peripheral insulin sensitivity, fat accumulation and related metabolic disorders, such as elevated FFA, low HMW–adiponectin and low grade inflammation.

Methods

• Researchers included 29 non-obese (BMI<25 kg/m2) Japanese patients with early type 2 diabetes mellitus.
• Based on intra-hepatic lipid (IHL) level measured by 1H-magnetic resonance spectroscopy, they categorized participants into the FL (IHL ≥5%, n=7) and non-FL groups (IHL<5%, n=22).

Results

• Evidence suggested that peripheral insulin sensitivity measured by hyperinsulinemic euglycemic clamp was ~25% lower in the FL group than in non-FL group, while hepatic insulin sensitivity was comparable between the two groups.
• The data demonstrated that the subcutaneous fat area was larger, free fatty acid level was higher, C-reactive protein was higher, and high molecular weight-adiponectin was lower in the FL group than the non-FL group.