Starr KNP, Connelly MA, Orenduff M, et al. - Via integrating data from Measuring Eating, Activity and Strength: Understanding the Response-Using Protein (MEASUR-UP) and Protein Optimization in Women Enables Results-Using Protein (POWER-UP) trials, researchers investigated how cardiometabolic health—assessed by lipids, lipoproteins, GlycA, trimethylamine-N-oxide, betaine, branched-chain amino acids, and Lipoprotein Insulin Resistance Index scores—could be influenced by two weight reduction diets: a higher protein diet offering balanced portions of lean beef and pork during the day vs a diet following the Recommended Daily Allowance-level of protein in obese middle-aged and older adults. They found that improvement in the risk markers of cardiovascular disease and type 2 diabetes in obese middle-aged and older adults was linked to consumption of a hypocaloric diet with either traditional (0.8 g/kg by weight [BW]/d) or higher protein (1.2 g/kg BW/d; predominantly from lean red meat) content. Both diets offered improvements in physical function without any adverse effect on cardiometabolic outcomes.