Zhang D, et al. - Researchers performed a prospective observational study to investigate the impact of thyroid hormones on the diagnostic and predictive accuracy of Cystatin C (Cys C) for acute kidney injury (AKI), and hence optimize the clinical application of Cys C. All patients were examined for serum creatinine (SCr), Cys C, and thyroid function, and were separated into five quintiles based on free triiodothyronine (FT3) and total triiodothyronine (TT3), and two categories according to the presence of low T3 syndrome or not. Outcomes suggest that the thyroid function had no meaningful impact on the diagnostic and predictive accuracy of Cys C in detecting AKI, but, was noted to affect the optimal cut-off value of Cys C to detect AKI.