Bailey-Davis L, Wood GC, Benotti P, et al. - A delayed onset of cardiometabolic diseases was observed in relation to sustained weight loss, especially with a greater magnitude of weight loss, in an integrated delivery network population.

• Obesity elevates the risk of developing type 2 diabetes, hypertension, and hyperlipidemia.

• A retrospective cohort study including 63,567 patients receiving primary care at Geisinger Health System between 2001 and 2017; of these, 67% were obesity maintainers (OM), 19% were weight loss rebounders (WLR), and 14% were weight loss maintainers (WLM).

• For WLM, the time until the development of electronic health record-documented type 2 diabetes, hypertension, and hyperlipidemia was longest, and it was shortest for OM.

• The lowest incident type 2 diabetes (adjusted hazard ratio 0.676), hypertension (0.723), and hyperlipidemia (0.864) was evident in WLM.

• A longer time to develop any of the outcomes (type 2 diabetes, hypertension, and hyperlipidemia) was observed in WLM with the greatest weight loss (>15%) vs those with the least amount of weight loss (<7%).