De Luca L, Gulizia MM, Gabrielli D, et al. - Greater burden of cardiovascular (CV) disease and worse quality of life were seen in chronic coronary syndromes (CCS) patients in the high tertile of serum uric acid (SUA). However, there was no significant impact of SUA on the higher rate of CV mortality, hospitalization for heart failure (HF) and major adverse CV events (MACE) observed in these patients during 1-year follow-up.

• Hyperuricemia has been linked with adverse CV events.

• Data from a nationwide, prospective registry were obtained for 2,394 CCS patients with available levels of SUA.

• Patients, based on SUA levels at baseline, were categorized as low tertile (n=860; 4.3 [3.7-4.7] mg/dL), middle tertile (n=739; 5.6 [5.3-5.9] mg/dL) and high tertile (n=795; 7.1 [6.7-7.9] mg/dL).

• MACE incidence at 1 year was 3.7%, 4.1% and 6.8% for low, middle and high tertiles, respectively.

• A significantly higher rate of CV mortality (1.4% vs 0.4%) and hospital admission for HF (2.8% vs 1.6%) was observed in the high vs the low tertile of SUA.

• However, MACE was not independently predicted by hyperuricemia [hazard ratio: 1.27].