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Impact of race on the association of mineral metabolism with heart failure: The Multi-Ethnic Study of Atherosclerosis

Journal of Clinical Endocrinology & Metabolism Mar 18, 2020

Robinson-Cohen C, Shlipak M, Sarnak M, et al. - Among participants from the Multi-Ethnic Study of Atherosclerosis, who were free of cardiovascular disease, researchers assessed if the links of mineral metabolism markers with heart failure (HF) varied by race and/or ethnicity. They quantified HF rates overall and across race and/or ethnic groups. This analysis included 6,413 participants. A median follow-up of 14.9 years was performed. For African Americans, the highest incidence rate for HF was reported, whereas it was lowest for Chinese. Among African Americans vs Whites, a higher prevalence of elevated parathyroid hormone (PTH) but not fibroblast growth factor-23 (FGF-23) was reported. In African American and Hispanic people included in a multiethnic population, a link of higher PTH and FGF-23 with HF risk was evident in this study. No evidence supporting race and/or ethnicity as modifiers of the link of altered mineral metabolism with risk of HF was generated.

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