Kvåle R, et al. - A total of 14,837 men (n = 13,198 included) treated with radical prostatectomy (RP) during the period 2001 to 2015 were recognized from the Cancer Registry of Norway in order to assess the influence of surgical margin status on following secondary treatment, palliative radiotherapy, and prostate cancer-specific mortality. Positive surgical margins (PSMs) were independently imminent of secondary treatment and palliative radiotherapy, subsequent to a median follow-up time of 5.2 years (3,591 individuals with ≥ 8 years of follow-up). Following 10 years, in individuals with PSMs, the absolute heightened risk for palliative radiotherapy following RP ranged between 0.1% in pT2 tumors with a Gleason score of 6, to 12% for pT3b tumors with a Gleason score of 9 to 10. PSMs were not independently correlated with prostate cancer-specific mortality. Thus, PSMs were associated with the progressed application of secondary treatment and palliative radiotherapy, however, they were not ominous of prostate cancer-specific mortality. Furthermore, dodging PSMs could be of the highest prognostic significance in patients with higher-risk disease features as the use of palliative radiotherapy was only slightly raised in individuals with PSMs and the lowest-risk disease features.