Wang C, et al. - Researchers focused on the influence of pigment dispersion on trabecular meshwork (TM) cells. They exposed porcine TM cells, from ab interno trabeculectomy specimens, to pigment dispersion. Thereafter, these were analyzed for alterations in morphology, immunostaining, and ultrastructure. They quantified the abilities of these cells to phagocytose migrate, and contraction. Attenuated phagocytosis and migration, as well as increased stress fiber formation and cell contraction were reported as the consequences of exposing TM cells to pigment dispersion. A central and early role of Rho signaling pathway was also demonstrated, indicating that pigmentary glaucoma could be treated with its inhibitors.