Peripheral artery disease (PAD) patients have higher risk for (cardiac) death after percutaneous coronary intervention (PCI), but not target vessel or lesion repeat revascularizations. A higher risk clinical profile of the PAD cohort was evident.

• The e‐ULTIMASTER registry was used to compare patients with and without known PAD undergoing PCI, and propensity-score was employed to adjust for differences between the groups.

• Of 33,880 patients, 2,255 (6.7%) had PAD, and older age with a higher burden of comorbidities was present in PAD patients.

• Less likelihood of presenting with STEMI and more chance of undergoing complex PCI was observed in patients with PAD.

• PAD was independently linked with 41% elevated risk for target lesion failure.

• A 75% and 103% higher risk for all cause death and for cardiac death, respectively, was observed.

• Regarding the rates of stent thrombosis, clinically driven target lesion revascularization, or MI, there was no difference.