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Impact of omalizumab in children from a middle-income country with severe therapy-resistant asthma: A real-life study

Pediatric Pulmonology Oct 18, 2017

Pitrez PM, et al. - This paper intended to illustrate the first clinical real-life experiences with omalizumab in Brazilian children with severe therapy-resistant asthma (STRA). A noticeable improvement in the disease control was discovered through omalizumab therapy. In addition, it decreased hospitalizations and permitted the suspension of continuous oral corticosteroids.

Methods

  • The design of this research was a retrospective study.
  • It enrolled children (6-18 years old) from a referral center who were diagnosed with STRA.
  • Patients underwent at least 6 months of omalizumab treatment and fulfilled the following initial criteria: 1) >6 years old; 2) a positive skin-prick test for at least one aeroallergen; and 3) a serum total IgE level between 30 and 1500 IU/mL.
  • A scrutiny was performed of the clinical and lung function variables prior to and after treatment.

Results

  • Fourteen children (mean age: 11.9 years; percentage female: 72%) were recruited.
  • A substantially increased control of the disease was achieved through the omalizumab treatment, according to a standardized questionnaire administered at every visit (P < 0.0001).
  • Hospitalizations ceased in 70% (P = 0.02) of patients, and 8/9 (89%) patients were permitted to be weaned off oral steroids (P = 0.004).

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