Hermon N, et al. - Researchers performed a prospective study on antenatal depression in pregnant women using patient-completed questionnaires. The women were hospitalized in a high-risk pregnancy department, and the goal of the study was to determine potential associations between maternal depression and adverse perinatal outcomes. The researchers compared hospitalized pregnant women who screened positive for depression to those who screened negative. Of the 279 women included in the study, 79 (28.3%) scored ≥ 10 points on the Edinburgh Postnatal Depression Scale (EPDS), screening positive for depression. After controlling for maternal age, ethnicity, gestational diabetes mellitus, pre-eclampsia, past preterm delivery, and gestational age upon admission, the multivariate regression model suggested that maternal antenatal depression during hospitalization is an independent risk factor for preterm delivery. These findings indicate that maternal antenatal depression in hospitalized women is common and that it is a significant predictor of preterm delivery.