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Impact of kidney function on cardiovascular risk and mortality: A comparison of South Asian and European cohorts

American Journal of Nephrology Nov 28, 2019

Eastwood S, et al. - In order to generate evidence on ethnic disparities in links between kidney function markers and mortality or cardiovascular disease (CVD), researchers undertook this baseline cross-sectional analysis and longitudinal follow-up study. They analyzed a UK population-based cohort, including 1,116 Europeans and 1,104 South Asians of mainly Indian descent, with age 52 ± 7 years at baseline (1988–1991). They found that South Asians vs Europeans had lower eGFRcys (CKD Epidemiology Collaboration (CKD-EPI) eGFR [estimated glomerular filtration rate] estimating equations based on serum cystatin C) and higher albumin-creatinine ratio (ACR). Compared with South Asians, a more strong link of eGFRcys and ­eGFRcreat (eGFR from CKD-EPI-creatinine equations) with outcomes was observed in Europeans. A greater utility of ACR in CVD risk prediction in South Asians was indicated by the identified strong links between ACR and results in South Asians of mainly Indian origin, and null links for eGFRcys and eGFRcreat.
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