Wasserman I, et al. - Researchers hypothesized that intravenous acetaminophen use, in isolation and in comparison to oral, would be associated with decreased opioid utilization (clinically significant reduction defined as 25%) and opioid-related adverse effects in open colectomy patients. To test this presumption, they separately classified oral and intravenous acetaminophen use: 1 (1,000 mg) or more than 1 dose on the day of surgery, postoperative day 1, or later, using national claims data from open colectomy patients. They observed marginal effects which did not support the idea of using intravenous acetaminophen routinely given alternative nonopioid analgesic options.