Carlier A, Dols A, Oudega M, et al. - Although, white matter hyperintensities (WMH), inflammation, depression and cognitive functioning are suggested to be intertwined, findings from this study indicate that patients with depression with or without WMH did not differ in the association between inflammation and cognition.

• The Mini-Mental State Examination was performed to assess cognitive functioning during and after a course of ECT in 77 older patients with depression.

• Prior to ECT, researchers collected serum samples (C-reactive protein [CRP], interleukin-6 [IL-6], interleukin-10 [IL-10] and tumor necrosis factor-alpha [TNF-α]) and 3T magnetic resonance imaging.

• Analysis suggested an interaction effect for IL-10, but not for CRP, IL-6 or TNF-α.