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Impact of HIV-status disclosure on HIV viral load in pregnant and postpartum women on antiretroviral therapy

Journal of Acquired Immune Deficiency Syndromes Jul 02, 2019

Brittain K, et al. - Researchers investigated the impact of HIV-status disclosure on HIV viral load (VL) during pregnancy and postpartum among 1187 women living with HIV, enrolled between March 2013 and June 2014 in Cape Town, South Africa. Observations revealed following 3 factors modify the impact of disclosure on VL: (1) timing of HIV diagnosis (before vs during the pregnancy); (2) relationship to the person(s) to whom women disclose; and (3) in the case of disclosure to a male partner, relationship status. They noted a reduced risk of VL ≥50 copies/mL at delivery in correlation to disclosure to a male partner among women who tested HIV-positive during pregnancy and initiated antiretroviral therapy subsequently. Only women who were married and/or cohabiting showed this association following stratification by relationship status. In addition, a reduced risk of VL ≥50 copies/mL at 12 months postpartum (adjusted risk ratio: 0.69; 95% confidence interval: 0.48 to 0.97) among newly-diagnosed women was observed in correlation to disclosure to ≥1 family/community member. Tailoring counseling about disclosure tailored to individual women's circumstances was suggested as most effective.
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