Impact of diabetes, angiotensin‐converting enzyme inhibitor or angiotensin ii receptor blocker use, and statin use on presentation and outcomes in patients with giant cell arteritis
International Journal of Rheumatic Diseases Aug 14, 2020
Ma J, Khalidi N, Wierzbicki O, et al. - Researchers conducted a retrospective chart review to simultaneously evaluate the effect of these 3 factors on a cohort of patients followed in 2 large Canadian centers (Hamilton and Toronto, ON). Between 1993 and 2015, researchers enrolled a total of 137 patients diagnosed with giant cell arteritis (GCA). This research compared presenting symptoms, temporal artery biopsies (TAB) results, disease complications and outcomes (relapses, duration of glucocorticoid use) between exposed (diabetes/angiotensin‐converting enzyme inhibitors/angiotensin II receptor blockers [ARB]/statin), and non‐exposed patients, with adjustment for main potential confounding variables. The outcomes suggested that diabetic individuals with GCA were less likely to have a positive TAB, and more likely to relapse. ARB therapy prior to diagnosis exhibited a correlation with success at discontinuing glucocorticoids. The clinical presentation or course of GCA was not altered after receiving statin therapy.
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